Preparation and Characterization of Trimethyl Chitosan Nanospheres Encapsulated with Tetanus Toxoid for Nasal Immunization Studies

نویسندگان

  • Mohsen Tafaghodi
  • Mona Zarifpour
  • Farzin Hadizadeh
  • Maryam Iman
چکیده

Article Type: Research Article Article History: Received: 28 May 2012 Accepted: 13 January 2013

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Nasal Immunization by (PLGA) Nanospheres Encapsulated with Tetanus Toxoid and (CpG-ODN)

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Nasal Immunization by (PLGA) Nanospheres Encapsulated with Tetanus Toxoid and (CpG-ODN)

In induction of systemic and mucosal immunity, particulate antigens are more effective than soluble antigens possibly because they are more efficiently endocytosed by mucosal-associated lymphoid tissue (MALT) M cells. In this study, we determined the systemic and mucosal immune responses in rabbits following intranasal immunization of tetanus toxoid TT and CpGODN encapsulated within PLGA nanosp...

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تاریخ انتشار 2013